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Card Consolidation Credit Debt       Mahidol University Annual Research Abstracts 2000 515 NO EVIDENCE OF CARDIOTOXICITY DURING ANTIMALARIAL TREATMENT WITH ARTEMETHER-LUMEFANTRINE

Credit Union van Vugt M,^1,2,3 Ezzet F,⁴ Nosten F,^1,3,5 Gathmann I,⁴ Wilairatana P,³ Looareesuwan S,³ White NJ1, ^{3,5 1}Shoklo Malaria Research Unit, Mae Sod, Thailand; ²Division of Infectious Disease, Tropical Medicine and AIDS, Academic Medical Centre, University of Amsterdam, The Netherlands; ³Faculty of Tropical Medicine, Mahidol University Bangkok, Thailand; ⁴Novartis Pharma AG, Basel, Switzerland; ⁵Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom.

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Apply Online For Credit Card                    Artemether and lumefantrine (benflumetol) is a new combination effective against multi drug resistant falciparum, malaria. Lumefantrine is a racemic fluorene derivative with the chemical name 2-dibutylamino-l-[2,7-dichloro-9-(4-chlorobenylidene)-9H-fluoren-4-yl]-ethanol. It conforms structurally, to the aryl-amino alcohol group of antimalarials including quinine, mefloquine and halofantrine. Other antimalarials notably quinine and to a greater extent quinidine and halofantrine, are known to prolog the QTc-interval at therapeutic dosages, and halofantrine has been associated with sudden death. Artemether, is a methyl-ether, derivative of dihydroartemisinin derived from artemisinin (Qinghaosu). Artemether and the closely elated compound arteether, given in high doses by intramuscular injection prolong the QTc-interval in rate and dogs, which has given rise to concern that similar effects could occur in clinical use, but there is no evidence from large prospective clinical studies of any cardiotoxicity with this compound in man. Artemether-lumefantrine has usually been given in a four dose regimen comprising 320 mg artemether and 1920 mg lumefantrine for adults. In Thailand two studies conducted with a 6-dose regimen which has proved highly effective and well tolerated. These large dose optimizing studies with higher dose regimens provided the opportunity to conduct detailed electrocardiographic studies and to relate an, changes observed to the plasma concentrations of lumefantrine.

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Credit Repair (The study was supported by the Wellcome Trust, Oxford Tropical Medicine Research Programme, 183 Euston Road London NW1 2BE, UK. Submitted to JID 1999). FREQUENCY OF PRURITUS IN PLASMODIUM VIVAX MALARIA PATIENTS TREATED WITH CHLOROQUINE IN THAILAND Valai Bussaratid,¹ Polrat Wilairatana,¹ Sivicha Krudsood,² Udomsak Silachamroon,¹ Douglas S. Walsh,³ Sornchai Looareesuwan ^{1 1}Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; ²Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; ³Department of Immunology and Medicine, U.S. Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.

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Credit Score                    Chloroquine-induced itch in black skinned African malaria patients is common and frequently leads to poor compliance or treatment defaulting. To assess the frequency and severity of chloroquine-induced pruritus in an Asian population, we reviewed case records of 1189 Plasmodium

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