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Card Consolidation Credit Debt       Mahidol University Annual Research Abstracts 2000 587 QINGHAOSU IN COMBINATIONS. White NJ^{1,2 1}Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; ²Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, U.K.

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Apply Online For Credit Card                       Antimalarial combinations make therapeutic sense. As we have few antimalarial drugs and even fewer in development, and as the malaria parasite shows a remarkable ability to develop resistance, all possible measures should be taken to protect those drugs that we do have available. Although in experimental animals combinations have been shown unequivocally to delay the onset of resistance, this has not yet been proved formally in human malaria. Yet formal proof is extremely difficult to obtain. However, there is sufficient circumstantial evidence to suggest that resistance can be delayed. As there are no counter arguments and the stakes are high, it seems reasonable that an artemisinin derivative should be combined with all slow acting antimalarial drugs. Those drugs with a particularly vulnerable profile, in which a single or double point mutation confers high level resistance, should not be deployed alone and should always be combined with an artemisinin derivative.

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By Card Credit Debt Debt Guide (Wellcome-Mahidol University, Oxford Tropical Medicine Research Programme funded by the Wellcome Trust of Great Britain. Published in Médecine Tropicale 1998; 58: 85-88.)   ARTEMISININ AND DERIVATIVES IN THE TREATMENT OF UNCOMPLICATED MALARIA. White NJ^1,2, Olliaro P^{3 1}Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; ²Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, U.K.; ³World Health Organisation, Geneva, Switzerland.

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Bad Car Credit Guide Loan                       Artemisinin and its derivatives are the most rapidly acting antimalarials known to-date and are well-tolerated. All derivatives in use today are produced by semi-synthesis from artemisinin: dihydroartemisinin is the product of the first step; more synthetic steps give rise to artesunate, artemether and arteether which are metabolised back to dihydroartemisinin in the body. Although their residence in the body after oral administration is very short (with half-lives of < 2 hours), they can be administered once daily. By acting on ring stages, they clear peripheral parasitaemia more quickly than other antimalarial drugs and prevent the development into mature sequestering blood stages. They are effective against all human malaria parasites, notably multidrug-resistant Plasmodium falciparum. They have anti-transmission properties, too. So far, resistance to this class of compounds has not been reported.

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