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Cost-Effectiveness Analysis Of Artesunate And Quinine

Card Consolidation Credit Debt       568 Faculty of Tropical Medicine COST-EFFECTIVENESS ANALYSIS OF ARTESUNATE AND QUININE + TETRACYCLINE FOR THE TREATMENT OF UNCOMPLICATED FALCIPARUM MALARIA IN CHANTHABURI, THAILAND Elsie R. Honrado1, Wijitr Fungladda2, Pirom Kamolratanakul3, Dwip Kitayaporn2, Juntra Karbwang4, Krongthong Thimasarn5 and Rungwit Masngammueng2 1 Research Institute for Tropical Medicine, Department of Health Alabang 1770, Muntinlupa City, Metro Manita, Philippines; 2Department of Social and Environmental Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand; 3 Department of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.; 4 Department of Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand. 5 Malaria Division, Ministry of Public Health, Nonthaburi 11000, Thailand.

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Merchant Credit Guide Co                     A randomized, controlled, malaria-clinic-based field trial was carried out to compare the cost-effectiveness of a 5-day 700-mg oral artesunate and a 7-day quinine + tetracycline regimen for the treatment of uncomplicated falciparum malaria in Thailand. Cost-effectiveness was determined from the providers' perspective and based on curative effectiveness. A total of 137 patients, aged 15-60 years, attending a malaria clinic were followed for 28 days, 60 of them received quinine + tetracycline and 77 received artesunate. Cure rates were assessed on day 5 (artesunate) and day 7 (quinine + tetracycline), using the intention-to-treat approach. Cost-effectiveness and sensitivity analysis were performed by varying the day 5/day 7 curative effectiveness and cost of artesunate. The cure rate with artesunate (100%) was more cost-effective than quinine + tetracycline (77.4%) (relative risk adjusted for sex (aRR) = 1.32, 95% confidence interval (CI) = 1.12-1.55; (referent quinine + tetracycline). Artesunate was more cost-effective than quinine + tetracycline at the following costs:artesunate, £ US$ 0.36 per 50-mg tablet; quinine, US$ 0.06 per 300-mg tablet; tetracycline, US$ 0.02 per 250-mg capsule; and services per case found, £ US$ 11.49. Because of the higher cure rate and higher cost-effectiveness of the artesunate regimen compared with quinine + tetracycline, we recommend its use for the treatment of uncomplicated falciparum malaria in malaria clinics in Thailand.

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By Card Credit Debt Debt Guide (This study was supported by the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases. Published in Bulletin of the World Health Organization 1999; 77(3) : 235-243.)

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