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Increased ovarian cancer risk not found in women with breast cancer family history

Card Consolidation Credit Debt Women with a strong family history of breast cancer but who don't have breast cancer genetic mutations can now be reassured that they are not at increased risk for ovarian cancer, according to a new study by researchers at Memorial Sloan-Kettering Cancer Center (MSKCC). The work, published in the September 21, 2005, issue of the Journal of the National Cancer Institute, is one of the first prospective studies to allow doctors to tailor ovarian cancer screening recommendations for women with a family history of breast cancer but with no identifiable BRCA mutation.

Researchers find a pair of breast cancer genes. Only 5 percent of breast cancers are hereditary. But among women who have families with a history of breast cancer and carry either the BRCA1 or BRCA2 gene (BRCA stands for "breast cancer"), the lifetime risk of breast cancer is about 80 percent, says Raymond L. White, Ph.D., director of the Huntsman Cancer Institute at the University of Utah Medical Center in Salt Lake City.

Credit Union In the ten years since the discovery of BRCA1 and BRCA2 genes, it has been learned that the risk for ovarian cancer in families with mutations in these genes is increased 6- to 61-fold. However, it has also emerged that up to half of families with multiple cases of breast cancer do not have mutations in either BRCA1 or BRCA2. Up until the current study, there has been limited data with which to inform such families as to their risk for ovarian cancer.

Cancer (Bladder) Most, but not all, published reports have shown coffee drinkers are at increased risk of bladder cancer. A review of 35 trials found a small (7%) increased risk of bladder cancer in coffee drinkers compared with people not drinking coffee––a difference that might have been due to chance. Cancer (Breast) Coffee drinking has been reported to increase breast pain associated with noncancerous lumps in the breast—a condition commonly called fibrocystic breast disease; some researchers believe some forms of fibrocystic breast disease increase the risk of breast cancer. However, coffee drinkers are at no higher risk of breast cancer than are women who do not drink coffee. Women wishing to reduce their risk of breast cancer do not need to avoid drinking coffee.

Merchant Credit Guide Co The MSKCC Clinical Genetics Service studied 199 families with multiple cases of breast cancer but no identified BRCA mutation. During follow-up, 19 new cases of breast cancer were diagnosed - three times more than the six cases that were expected. Only one case of ovarian cancer was diagnosed, which is what researchers would have anticipated in an average risk population.

WEDNESDAY, May 30 (HealthDay News) - The products will not increase their risk of breast cancer, a new study finds.

Apply Online For Credit Card While the authors conclude that women from these families do not have an increased risk of ovarian cancer, they also indicate that the genetic mechanism for up to half of hereditary breast cancer remains unknown. Ongoing research at MSKCC, in collaboration with other scientists in the US, Canada, and Israel, is underway to map undiscovered genes associated with hereditary breast cancer.

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By Card Credit Debt Debt Guide Memorial Sloan-Kettering Cancer Center

Breast cancer. "We're finding that many cancers, including breast cancer, have a strong genetic component. Estrogen may not be much of a factor, " says Dr. Goldfarb. Still, if a woman is genetically at risk, it is possible that estrogen may activate the gene that gets breast cancers started, he adds. "If a patient's mother and sister had breast cancer, I would caution her that hormone replacement therapy may increase her risk, " he says.

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